PTBP1 (polypyrimidine tract binding protein 1)

The RNA-Binding Protein, Polypyrimidine Tract-Binding Protein 1 (PTBP1) Is a Key Regulator of CD4 T Cell Activation

We have previously shown that the RNA binding protein, polypyrimidine tract-binding protein (PTBP1) plays a critical role in regulating the expression of CD40L in activated CD4 T cells. This is achieved mechanistically through message stabilization at late times of activation as well as by altered distribution of CD40L mRNA within distinct cellular compartments. PTBP1 has been implicated in man...

Polypyrimidine Tract-Binding Protein Is

Exon repression by polypyrimidine tract binding protein.

Polypyrimidine tract binding protein (PTB) is known to silence the splicing of many alternative exons. However, exons repressed by PTB are affected by other RNA regulatory elements and proteins. This makes it difficult to dissect the structure of the pre-mRNP complexes that silence splicing, and to understand the role of PTB in this process. We determined the minimal requirements for PTB-mediat...

Polypyrimidine Tract-Binding Protein Down-Regulates

Exclusion of the -exon by alternative RNA splicing of the fibroblast growth factor receptor 1 (FGFR1) primary transcript leads to the production of FGFR1 . Glial cell transformation is associated with a progressive increase in FGFR1 expression that coincides with a dramatic increase in the expression of the splicing factor polypyrimidine tractbinding protein (PTB). Cell-specific overexpression ...

Polypyrimidine tract binding protein antagonizes exon definition.